July 20, 2014
"the time and money required for each new therapeutic undertaken by a conventional pharmaceutical company is roughly equivalent to what it took to complete the Human Genome Project"

Individualized Cancer Treatment Coming — But Only If Underdogs Prevail

July 12, 2014

Generally, health is just so heavily regulated. It’s just a painful business to be in. It’s just not necessarily how I want to spend my time. Even though we do have some health projects, and we’ll be doing that to a certain extent. But I think the regulatory burden in the U.S. is so high that think it would dissuade a lot of entrepreneurs. … it’s so heavily regulated. It’s a difficult area.

I can give you an example. Imagine you had the ability to search people’s medical records in the U.S.. Any medical researcher can do it. Maybe they have the names removed. Maybe when the medical researcher searches your data, you get to see which researcher searched it and why. I imagine that would save 10,000 lives in the first year. Just that. That’s almost impossible to do because of HIPPA. I do worry that we regulate ourselves out of some really great possibilities that are certainly on the data-mining end.


Fireside chat with Google co-founders, Larry Page and Sergey Brin | Khosla Ventures

June 28, 2014
Larry Summers: Median wages vs. productivity

"during a period in which median wages have been stagnant over the last
30 years, median wages in terms of automobiles have almost doubled”

May 7, 2014
"History is filled with the sound of silken slippers going downstairs and wooden shoes coming up."

Voltaire and his Wise Quotes

March 21, 2014
"RunKeeper’s strategy : being a motivational tool that sits on top of data collection and feedback tools, rather than hanging its hat on data collection and feedback itself."

RunKeeper CEO: Dedicated trackers are headed the way of the digital camera | mobihealthnews

February 28, 2014
"[Steve Jobs] said: ‘You have to understand. This is something that nobody in the world yet understands. I can’t be distracted. I’m trying to make the best hammer I can make, the best hammer in the world. You can use my hammer to tear something down, or you can use it to build something up. I really don’t care what you do with my hammer. I just want to make the best possible hammer. And what you are doing is a wonderful bit of construction, but to me it’s a distraction."

Steve Jobs Rejected The First Medical App In 1977

December 14, 2013
23andme App Done


Well, that didn’t take long. Less than seven hours after I posted a request and reward for a 23andme app, I had two submissions. Beau Gunderson and Eric Jain (who turn out to be friends) both submitted short programs that fulfilled my request. The winning version is at Beau’s site.

First, a…

This is great! Thanks for setting this up!

November 26, 2013
"[JC Penney] was selling fewer than one out of every 500 items at full price. Customers were receiving an average discount of 60%, up from 38% a decade earlier. The twist is they weren’t saving more. In fact, the average price paid by customers stayed about the same over that period. What changed was the initial price, which increased by 33%."

The Dirty Secret of ‘Discounts’—Black Friday and Beyond - WSJ.com

November 21, 2013
The New Economy

Larry Summers:

a surprisingly large chunk of our male population is now in the position where there is nothing that people can think of for them to do that is useful enough to cover the costs of making sure that they actually do it correctly, and don’t break the stuff and subtract value when they are supposed to be adding to it.

This is the most serious economics trend out there. Technology is replacing skills so quickly that even occupations once considered “safe” are becoming obsolete.

(Source: delong.typepad.com)

November 20, 2013
Myanmar modernizes

“No one would choose to work on the road­side,” said Mr. Say Thu, who tries to sup­port his wife and chil­dren on an in­come of about $200 a month. “We would pre­fer to be in­doors.”

This is the type of person who will be working in a factory soon, perhaps under conditions that latte-sipping, well-intentioned Americans will think too cruel. 

I’m also reminded of my surprise, during my visit there, of the high prices for many/most of the handmade items. Even (especially) labor-intensive products like hand-sewn scarves seemed expensive and often not particularly high-quality compared to similar items from Thailand or Vietnam. 

The reason: little to no automation. Blocking themselves from the outside world for so long made Burma poor.

(Source: The New York Times)